Journal of Substance Abuse Treatment
Volume 28, Issue 4 , Pages 321-329 , June 2005

An overview of systematic reviews of the effectiveness of opiate maintenance therapies: available evidence to inform clinical practice and research

  • Laura Amato

      Affiliations

    • Department of Epidemiology, 00198 Rome, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 6 8306 0479; fax: +39 6 8306 0463
  • ,
  • Marina Davoli

      Affiliations

    • Department of Epidemiology, 00198 Rome, Italy
  • ,
  • Carlo A.Perucci

      Affiliations

    • Department of Epidemiology, 00198 Rome, Italy
  • ,
  • Marica Ferri

      Affiliations

    • Department of Epidemiology, 00198 Rome, Italy
  • ,
  • Fabrizio Faggiano

      Affiliations

    • Department of Public Health, Regional Monitoring Centre for Drug Abuse, University of Torino, Turin, Italy
  • ,
  • Richard P. Mattick

      Affiliations

    • National Drug and Alcohol Research Centre, University of New South Wales, Sydney, New South Wales, Australia

Received 3 January 2005 ,Revised 4 February 2005 ,Accepted 25 February 2005.

References 

  1. Amato L, Davoli M, Ferri M, Gowing L, Perucci CA. Effectiveness of interventions on opiate withdrawal treatment: An overview of systematic reviews. Drug and Alcohol Dependence. 2004;73:219–226
  2. Bargagli AM, Sperati A, Davoli M, Forastiere F, Perucci CA. Mortality among problem drug users in Rome: An 18-year follow-up study, 1980–97. Addiction. 2001;96:1455–1463
  3. Bird SM, Hutchinson SJ. Male drugs-related deaths in the fortnight after release from prison: Scotland, 1996–99. Addiction. 2003, February;98:185–190
  4. Brettle RP. HIV and harm reduction for injection drug users. AIDS. 1991;5:125–136
  5. Caplehorn JRM, Bell J. Methadone dosage and retention of patients in maintenance treatment. Medical Journal of Australia. 1991;154:195–199
  6. Caplehorn JRM, Dalton MSYN, Cluff MC, Petrenas AM. Retention in methadone maintenance and heroin addicts' risk of death. Addiction. 1994;89:203–207
  7. Caplehorn JRM, Irwig L, Saunders JB. Physicians' attitudes and retention of patients in their methadone maintenance programs. Substance Use & Misuse. 1996;31:663–677
  8. Clark N, Lintzeris N, Gijsbers A, Whelan G, Ritter A, Dunlop A. LAAM maintenance vs methadone maintenance for heroin dependence. The Cochrane Library, Issue 3. Oxford: Update Software; 2003;
  9. Darke S, Hall W. Heroin overdose: Research and evidence-based intervention. Journal of Urban Health. 2003;80:189–200
  10. Davoli M, Ferri M. The Cochrane Review Group on Drugs and Alcohol. Addiction. 2000;95:1473–1474
  11. Davoli M, Perucci CA, Rapiti E, Bargagli AM, D'Ippoliti D, Forastiere F, et al. A persistent rise in mortality among injecting drug users in Rome, 1980 through 1992. American Journal of Public Health. 1997;87:851–853
  12. Del Rio M, Mino A, Perneger TV. Predictors of patient retention in a newly established methadone maintenance treatment programme. Addiction. 1997;92:1353–1360
  13. D'Ippoliti D, Davoli M, Perucci CA, Pasqualini F, Bargagli AM. Retention in treatment of heroin users in Italy: The role of treatment type and of methadone maintenance dosage. Drug and Alcohol Dependence. 1998;52:167–171
  14. Dole V, Robinson J, Orraca J, Towns E, Searcy P, Caine E. Methadone treatment of randomly selected criminal addicts. New England Journal of Medicine. 1969;280:1372–1375
  15. Dole VP, Nyswander ME. Heroin addiction—a metabolic disease. Archives of Internal Medicine. 1967, July;120:19–24
  16. European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). Annual report (2003): The state of the drugs problem in the European Union and Norway. Lisbon, Portugal: Author; 2003;
  17. Faggiano F, Versino E, Vigna-Taglianti F, Lemma P. Methadone maintenance at different dosages for opioid dependance. The Cochrane Library, Issue 3. Oxford: Update Software; 2003;
  18. Farrell M, Ward J, Mattick RP, Hall W, Stimson GV, des Jarlais D, et al. Methadone maintenance treatment in opiate dependence: A review. British Medical Journal. 1994;309:997–1001
  19. Ferri M, Davoli M, Perucci CA. Heroin maintenance for chronic heroin dependence. The Cochrane Library, Issue 3. Oxford: Update Software; 2003;
  20. Fischer G, Gombas W, Eder H, Jagsch R, Peternell A, Stuehlinger G, et al. Buprenorphine versus methadone maintenance for the treatment of opioid dependence. Addiction. 1999;94:1337–1347
  21. Freedman RR, Czertko G. A comparison of thrice weekly LAAM and daily methadone in employed heroin addicts. Drug and Alcohol Dependence. 1981;8:215–222
  22. Frischer M, Goldberg D, Rahman M, et al. Mortality and survival among a cohort of drug injectors in Glasgow, 1982–1994. Addiction. 1997;92:419–427
  23. Gaughwin M, Solomon P, Ali R. Correlates of retention on the South Australian Methadone Program 1981–91. Australian and New Zealand Journal of Public Health. 1998;22:771–776
  24. Goldstein A, Herrera J. Heroin addicts and methadone treatment in Albuquerque: A 22-year follow-up. Drug and Alcohol Dependence. 1995;40:139–150
  25. Goldstein A, Judson B. Three critical issues in the management of methadone programs: Critical Issue 3: Can the community be protected against the hazards of take-home methadone. In:  Bourne P editors. Addiction. New York: Academic Press; 1974;p. 140–148
  26. Goldstein A, Judson BA. Efficacy and side effects of three widely different methadone doses. Proceedings of the National Conference on Methadone Treatment. 1973;1:21–44
  27. Gossop M, Marsden J, Stewart D, Treacy S. Outcomes after methadone maintenance and methadone reduction treatments: Two-year follow-up results from the National Treatment Outcome Research Study. Drug and Alcohol Dependence. 2001;62:255–264
  28. Grevert P, Masover B, Goldstein A. Failure of methadone and levomethadyl acetate (levo-alpha-acetylmethadol, LAAM) maintenance to affect memory. Archives of General Psychiatry. 1977;34:849–853
  29. Gunne L, Gronbladh L. The Swedish Methadone Maintenance Program: A controlled study. Drug and Alcohol Dependence. 1981;7:249–256
  30. Haastrup S, Jepsen PW. Seven year follow-up of 300 young drug abusers. Acta Psychiatrica Scandinavica. 1984;70:503–509
  31. Hall W. Methadone maintenance treatment as a crime control measure. [letter, see comments] British Medical Journal. 1996;312:1162
  32. Hartnoll RL. Evaluation of heroin maintenance in controlled trial. Archives of General Psychiatry. 1980;37:877–884
  33. Hickman M, Madden P, Henry J, Baker A, Wallace C, Wakefield J, et al. Trends in drug overdose deaths in England and Wales 1993–98: Methadone does not kill more people than heroin. Addiction. 2003, April;98:387–388
  34. Hser Y, Anglin MD, Powers K. A 24-year follow-up of California narcotics addicts. Archives General of Psychiatry. 1993;50:577–584
  35. Hulse GK, English DR, Milne E, Holman CD. The quantification of mortality resulting from the regular use of illicit opiates. Addiction. 1999, February;94:221–229
  36. Irwin S, Blachly PH, Marks J, Carlson E, Loewen J, Reade N. The behavioral, cognitive and physiologic effects of long-term methadone and methadyl treatment. NIDA Research Monograph. 1976;8:66–67
  37. Johnson R, Jaffe J, Fudala P. A controlled trial of buprenorphine treatment for opioid dependence. Journal of the American Medical Association. 1992;267:2750–2755
  38. Johnson RE, Chatupe MA, Strain E, Walsh S, Stitzer ML, Bigelow GE. A comparison of levomethadyl acetate, buprenorphine, and methadone for opioid dependence. New England Journal of Medicine. 2000;343:1290–1297
  39. Johnson RE, Eissenberg T, Stitzer M, Strain E, Liebson I, Bigelow G. A placebo controlled trial of buprenorphine as a treatment for opioid dependence. Drug and Alcohol Dependence. 1995;40:17–25
  40. Karp-Gelernter E, Savage C, McCabe OL. Evaluation of clinic attendance schedules for LAAM and methadone: A controlled study. International Journal of the Addictions. 1982;17:805–813
  41. Kosten T, Schottenfeld R, Ziedonis D, Falcioni J. Buprenorphine versus methadone maintenance for opioid dependence. Journal of Nervous and Mental Disease. 1993;181:358–364
  42. Lehmann WX. The use of l-alpha-acetyl-methadol (LAAM) as compared to methadone in the maintenance and detoxification of young heroin addicts. 1973. [proceedings] NIDA Research Monograph. 1976;8:82–83
  43. Leshner AI. Drug addiction research: Moving toward the 21st century. Drug and Alcohol Dependence. 1998;51:5–7
  44. Ling W, Charuvastra C, Collins J, Batki S, Brown L, Kintaudi P, et al. Buprenorphine maintenance treatment of opiate dependence: A multicenter, randomized clinical trial. Addiction. 1998;93:475–486
  45. Ling W, Charuvastra C, Kaim SC, Klett CJ. Methadyl acetate and methadone as maintenance treatments for heroin addicts. A veterans administration cooperative study. Archives of General Psychiatry. 1976;33:709–720
  46. Ling W, Klett CJ, Gillis RD. A cooperative clinical study of methadyl acetate. I. Three-times-a-week regimen. Archives of General Psychiatry. 1978;35:345–353
  47. Ling W, Wesson D, Charuvastra C, Klett J. A controlled trial comparing buprenorphine and methadone maintenance in opioid dependence. Archives of General Psychiatry. 1996;53:401–407
  48. Maddux JF, Prihoda TJ, Vogtsberger KN. The relationship of methadone dose and other variables to outcomes of methadone maintenance. American Journal on Addictions. 1997;6:246–255
  49. Marcovici M, O'Brien CP, McLellan AT, Kacian J. A 1981 clinical, controlled study of l-alpha-acetylmethadol in the treatment of narcotic addiction. American Journal of Psychiatry. 1981;138:234–236
  50. Mattick RP, Ali R, White J, O'Brien S, Wolk S, Danz CA. Buprenorphine versus methadone maintenance therapy: A randomized double-blind trial with 405 opioid-dependent patients. Addiction. 2003, April;98:441–452
  51. Mattick RP, Breen C, Kimber J. Methadone maintenance versus no opioid replacement therapy for opioid dependence. The Cochrane Library, Issue 3. Oxford: Update Software; 2003;
  52. Mattick RP, Degenhardt L. Methadone-related and heroin-related deaths among opiate users: Methadone helps save lives. Addiction. 2003, April;98:387–388
  53. Mattick RP, Kimber J, Breen C. Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence. The Cochrane Library, Issue 3. Oxford: Update Software; 2003;
  54. McLellan T, Lewis DC, O'Brien CP, Kleber HD. Drug dependence, a chronic medical illness. Implications for treatment, insurance, and outcomes evaluation. Journal of American Medical Association. 2000;284:1689–1695
  55. Newman R, Whitehill W. Double-blind comparison of methadone and placebo maintenance treatments of narcotic addicts in Hong Kong. Lancet. 1979, September;8:485–488
  56. O'Brien CP. A range of research-based pharmacotherapies for addiction. Science. 1997;278:66–70
  57. Oliver P, Keen J. Concomitant drugs of misuse and drug using behaviours associated with fatal opiate-related poisonings in Sheffield, UK, 1997–2000. Addiction. 2003, February;98:191–197
  58. Ortì RM, Domingo-Salvany A, Munoz A, et al. Mortality trends in a cohort of opiate addicts, Catalonia, Spain. International Journal of Epidemiology. 1996;25:545–553
  59. Pani P, Maremmani I, Pirastu R, Tagliamonte A, Gessa G. Buprenorphine: A controlled trial in the treatment of opioid dependence. Drug and Alcohol Dependence. 2000;60:39–50
  60. Perneger TV, Giner F, del Rio M, Mino A. Randomised trial of heroin maintenance programme for addicts who fail in conventional drug treatments. British Medical Journal. 1998;317:13–18
  61. Petitjean S, Stohler R, Deglon J, Livoti S, Waldvogel D, Uehlinger C, et al. Double blind randomized trial of buprenorphine and methadone in opiate dependence. Drug and Alcohol Dependence. 2001;62:97–104
  62. Preston KL, Umbricht A, Epstein DH. Methadone dose increase and abstinence reinforcement for treatment of continued heroin use during methadone maintenance. Archives of General Psychiatry. 2000;57:395–404
  63. Resnick RB, Washton AM, Garwood J, Perzel J. LAAM instead of take-home methadone. NIDA Research Monograph. 1982;41:473–475
  64. Rhoades HM, Creson D, Ronith E, Schmitz J, Grabowski J. Retention, HIV risk, and illicit drug use during treatment: Methadone dose and visit frequency. American Journal of Public Health. 1998;88:34–39
  65. Ritter A, Lintzeris N, Kutin J, Bammer G, Clark N, Panjari M, et al. LAAM Implementation Trial. Melbourne, Australia: Turning Point Alcohol & Drug Centre; 2001;
  66. Sanchez J, Rodriguez B, de la Fuente L, Barrio G, Vicente J, Roca J, et al. Opiates or cocaine: Mortality from acute reactions in six major Spanish cities. State Information System on Drug Abuse (SEIT) Working Group. Journal of Epidemiology and Community Health. 1995;49:54–60
  67. Savage C, Karp EG, Curran SF, Hanlon TE, McCabe OL. Methadone/LAAM maintenance: A comparison study. Comprehensive Psychiatry. 1976;17:415–424
  68. Schottenfeld R, Pakes J, Oliveto A, Ziedonis D, Kosten T. Buprenorphine vs methadone maintenance treatment for concurrent opioid dependence and cocaine abuse. Archives of General Psychiatry. 1997;54:713–720
  69. Senay EC, Dorus W, Renault PF. Methadyl acetate and methadone. An open comparison. JAMA. 1977;237:138–142
  70. Senay EC, Jaffe JH, Dimenza S, Renault PF. A 48-week study of methadone, methadyl acetate, and minimal services. 1976. [proceedings] NIDA Research Monograph. 1976;8:88–89
  71. Simpson DD, Joe GW, Dansereau DF, Chatham LR. Strategies for improving methadone treatment process and outcome. Journal of Drug Issues. 1997;27:239–260
  72. Sporer KA. Acute heroin overdose. Annals of Internal Medicine. 1999;130:584–590
  73. Strain E, Stitzer M, Leibson I, Bigelow G. Dose–response effects of methadone in the treatment of opioid dependence. Annals of Internal Medicine. 1993;119:23–27
  74. Strain E, Stitzer M, Liebson I, Bigelow G. Buprenorphine versus methadone in the treatment of opioid dependent cocaine users. Psychopharmocology. 1994;116:401–406(1995215552)
  75. Strain E, Stitzer M, Liebson I, Bigelow G. Comparison of buprenorphine and methadone in the treatment of opioid dependence. American Journal of Psychiatry. 1994;151:1025–1030
  76. Strain EC, Bigelow GE, Liebson IA, Stitzer ML. Moderate- vs high-dose methadone in the treatment of opioid dependence: A randomized trial. Journal of the American Medical Association. 1999;281:1000–1005
  77. Strang J, Mc Cambridge J, Best D, Beswick T, Bearn J, Rees S, et al. Loss of tolerance and overdose mortality after inpatient opiate detoxification: Follow-up study. British Medical Journal. 2003;326:959–960
  78. Torrens M, Castillo C, Pérez-Solà V. Retention in a low-threshold methadone maintenance program. Drug and Alcohol Dependence. 1996;41:55–59
  79. United Nations International Drug Control Programme (UNIDCP) . World drug report. New York: Oxford University Press; 1997;
  80. United Nations International Drug Control Programme (UNIDCP) . World drug report. New York: Oxford University Press; 2001;
  81. Van Ameijden EJC, Langendam MW, Coutinho RA. Dose–effect relationship between overdose mortality and prescribed methadone dosage in low-threshold maintenance programs. Addictive Behaviors. 1999;24:559–563
  82. van den Brink W, Hendriks VM, Blanken P, Koeter WJ, van Zwieten BJ, van Ree JM. Medical prescription of heroin to treatment resistant heroin addicts: Two randomised controlled trials. British Medical Journal. 2003;327:310–316
  83. Vanichseni S, Wongsuwan B, The Staff of BMA Narcotics Clinic No. 6 , Choopanya K, Wongpanich K. A controlled trial of methadone in a population of intravenous drug users in Bangkok: Implications for prevention of HIV. International Journal of the Addictions. 1991;26:1313–1320
  84. Ward J, Hall W, Mattick RP. Role of maintenance treatment in opioid dependence. Lancet. 1999;353:221–226
  85. White JM, Danz C, Kneebone J, La Vincente S, Newcombe D, Ali R. Relationship between LAAM–methadone preference and treatment outcomes. Drug and Alcohol Dependence. 2002;66:295–301
  86. Yancovitz S, Des Jarlais D, Peskoe Peyser N, Drew E, Friedman P, Trigg H, et al. A randomized trial of an interim methadone maintenance clinic. American Journal of Public Health. 1991;81:1185–1191
  87. Zaks A, Fink M, Freedman AM. Levomethadyl in maintenance treatment of opiate dependence. Journal of the American Medical Association. 1972;220:811–813

PII: S0740-5472(05)00049-8

doi: 10.1016/j.jsat.2005.02.007

Journal of Substance Abuse Treatment
Volume 28, Issue 4 , Pages 321-329 , June 2005